High-resolution x-ray CT screening of mutant mouse models

Michael J. Paulus; Shaun S. Gleason; Hamed Sari-Sarraf; Dabney K. Johnson; Charmaine J. Foltz; Derek W. Austin; M. Evangeline Easterly; Edward J. Michaud; Madhu S. Dhar; Patricia R. Hunsicker; J. W. Wall; M. Schell

doi:10.1117/12.384221

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27 April 2000 High-resolution x-ray CT screening of mutant mouse models

Michael J. Paulus, Shaun S. Gleason, Hamed Sari-Sarraf, Dabney K. Johnson, Charmaine J. Foltz, Derek W. Austin, M. Evangeline Easterly, Edward J. Michaud, Madhu S. Dhar, Patricia R. Hunsicker, J. W. Wall, M. Schell

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Proceedings Volume 3921, Optical Diagnostics of Living Cells III; (2000) https://doi.org/10.1117/12.384221
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

A dedicated small animal x-ray computed tomography system has been developed to screen mutagenized mice for anatomical phenotypes. The key components of the data acquisition instrumentation are described along with the system performance parameters. Image reconstruction, visualization and segmentation software algorithms are described. Two contrast media regimens are described and representative studies of mice with adipose, soft and skeletal tissue abnormalities are presented.

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Michael J. Paulus, Shaun S. Gleason, Hamed Sari-Sarraf, Dabney K. Johnson, Charmaine J. Foltz, Derek W. Austin, M. Evangeline Easterly, Edward J. Michaud, Madhu S. Dhar, Patricia R. Hunsicker, J. W. Wall, and M. Schell "High-resolution x-ray CT screening of mutant mouse models", Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); https://doi.org/10.1117/12.384221

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