Proton pumps, angiogenesis, and metastatic breast cancer

Jose D. Rojas; Shankar C. Sanka; Defeng Luo; Christian Busch; Gloria M. Martinez; Mary J. C. Hendrix; Raul Martinez-Zaguilan

doi:10.1117/12.384241

26 April 2000 Proton pumps, angiogenesis, and metastatic breast cancer

Jose D. Rojas, Shankar C. Sanka, Defeng Luo, Christian Busch, Gloria M. Martinez, Mary J. C. Hendrix, Raul Martinez-Zaguilan

Author Affiliations +

Proceedings Volume 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation; (2000) https://doi.org/10.1117/12.384241
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We have previously shown the relationship between metastatic potential and plasmalemmal V-H⁺-ATPase (pmV-ATPase) expression in tumor cells. This led us to hypothesize that pmV-ATPase activity is involved in invasion. Angiogenesis involves invasion of adjacent tissues by microvascular endothelial cells, thus we hypothesized that pmV-ATPases contribute to pHⁱⁿ regulation and invasion in microvascular endothelial cells.

Citation Download Citation

Jose D. Rojas, Shankar C. Sanka, Defeng Luo, Christian Busch, Gloria M. Martinez, Mary J. C. Hendrix, and Raul Martinez-Zaguilan "Proton pumps, angiogenesis, and metastatic breast cancer", Proc. SPIE 3924, Molecular Imaging: Reporters, Dyes, Markers, and Instrumentation, (26 April 2000); https://doi.org/10.1117/12.384241

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