Volumetric monochromatic x-ray tomography of the lungs

Cynthia B. Paschal; Frank Edward Carroll M.D.; John A. Worrell; Marcus H. Mendenhall; Robert H. Traeger; James W. Waters; Caryl N. Brzymialkiewicz; Gwen A. Banks

doi:10.1117/12.384251

28 April 2000 Volumetric monochromatic x-ray tomography of the lungs

Cynthia B. Paschal, Frank Edward Carroll M.D., John A. Worrell, Marcus H. Mendenhall, Robert H. Traeger, James W. Waters, Caryl N. Brzymialkiewicz, Gwen A. Banks

Author Affiliations +

Proceedings Volume 3925, Biomedical Applications of Free-Electron Lasers; (2000) https://doi.org/10.1117/12.384251
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Monochromatic x-rays were produced by inverse Compton scattering resolution from counter-propagation of a tunable free electron laser electron beam and its own infrared photon beam. In a manner analogous to electron beam CT, a mechanism was developed here for obtaining multiple projection views with monochromatic x-rays by deflecting x- rays off of mosaic crystals mounted on rotating stages. These crystals are both energy and angle selective. X-rays are detected digitally when they strike a phosphorescent screen mounted in front of a CCD camera. Using this system, multiple projection images of a 3D phantom and of rat lungs ex vivo were obtained. In an alternate micro-CT arrangement, rat lungs in situ were imaged by rotating the rat in front of both a polychromatic beam from a molybdenum target x-ray tube and the same beam monochromatized with a mosaic crystal. In the first arrangement, depth information was revealed by relative position changes of features seen in each projection and the approximately 0.16 mm thick walls of a catheter were visible in the images. Using conventional tomography, the projections were reconstructed into slice images. Overall, these monochromatic x-ray imaging methods offer reduced x-ray dose, the potential for improved contrast resolution, and now 3D information.

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Cynthia B. Paschal, Frank Edward Carroll M.D., John A. Worrell, Marcus H. Mendenhall, Robert H. Traeger, James W. Waters, Caryl N. Brzymialkiewicz, and Gwen A. Banks "Volumetric monochromatic x-ray tomography of the lungs", Proc. SPIE 3925, Biomedical Applications of Free-Electron Lasers, (28 April 2000); https://doi.org/10.1117/12.384251

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