Volumetric monochromatic x-ray tomography of the lungs

Cynthia B. Paschal; Frank Edward Carroll M.D.; John A. Worrell; Marcus H. Mendenhall; Robert H. Traeger; James W. Waters; Caryl N. Brzymialkiewicz; Gwen A. Banks

doi:10.1117/12.384251

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28 April 2000 Volumetric monochromatic x-ray tomography of the lungs

Cynthia B. Paschal, Frank Edward Carroll M.D., John A. Worrell, Marcus H. Mendenhall, Robert H. Traeger, James W. Waters, Caryl N. Brzymialkiewicz, Gwen A. Banks

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Proceedings Volume 3925, Biomedical Applications of Free-Electron Lasers; (2000) https://doi.org/10.1117/12.384251
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Monochromatic x-rays were produced by inverse Compton scattering resolution from counter-propagation of a tunable free electron laser electron beam and its own infrared photon beam. In a manner analogous to electron beam CT, a mechanism was developed here for obtaining multiple projection views with monochromatic x-rays by deflecting x- rays off of mosaic crystals mounted on rotating stages. These crystals are both energy and angle selective. X-rays are detected digitally when they strike a phosphorescent screen mounted in front of a CCD camera. Using this system, multiple projection images of a 3D phantom and of rat lungs ex vivo were obtained. In an alternate micro-CT arrangement, rat lungs in situ were imaged by rotating the rat in front of both a polychromatic beam from a molybdenum target x-ray tube and the same beam monochromatized with a mosaic crystal. In the first arrangement, depth information was revealed by relative position changes of features seen in each projection and the approximately 0.16 mm thick walls of a catheter were visible in the images. Using conventional tomography, the projections were reconstructed into slice images. Overall, these monochromatic x-ray imaging methods offer reduced x-ray dose, the potential for improved contrast resolution, and now 3D information.

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Cynthia B. Paschal, Frank Edward Carroll M.D., John A. Worrell, Marcus H. Mendenhall, Robert H. Traeger, James W. Waters, Caryl N. Brzymialkiewicz, and Gwen A. Banks "Volumetric monochromatic x-ray tomography of the lungs", Proc. SPIE 3925, Biomedical Applications of Free-Electron Lasers, (28 April 2000); https://doi.org/10.1117/12.384251

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