Compact phase-sensitive multichannel detection system with array measurements of biosensor chips

Emmanuil M. Rabinovich; Michael J. O'Brien II; Steven R. J. Brueck; S. Yang; Victor H. Perez-Luna; Gabriel P. Lopez

doi:10.1117/12.380510

22 March 2000 Compact phase-sensitive multichannel detection system with array measurements of biosensor chips

Emmanuil M. Rabinovich, Michael J. O'Brien II, Steven R. J. Brueck, S. Yang, Victor H. Perez-Luna, Gabriel P. Lopez

Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380510
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

In many medical, biological, chemical, and environmental applications it is desirable not only to monitor one specific chemical or biological species, but several simultaneously. Thus, we have focused our efforts on development of a detection system for multi-analyte sensor arrays that is able to monitor the changes in fluorophore lifetimes (via the detection of phase shifts) corresponding to the presence of many analytes of interest in near-real time. We describe a phase-sensitive electronic detection system employing a multianode photomultiplier tube. This system utilizes the frequency-domain method of time-resolved spectroscopy and is also suitable for lifetime-based imaging.

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Emmanuil M. Rabinovich, Michael J. O'Brien II, Steven R. J. Brueck, S. Yang, Victor H. Perez-Luna, and Gabriel P. Lopez "Compact phase-sensitive multichannel detection system with array measurements of biosensor chips", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); https://doi.org/10.1117/12.380510

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KEYWORDS

Sensors

Luminescence

Biosensors

Imaging systems

Self-assembled monolayers

Fiber optics

Molecules

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