Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry

David H. Russell; Kent J. Gillig; Earle Stone; Zee-Yong Park; K. Fuhrer; M. Gonon; A. J. Schultz

doi:10.1117/12.380496

22 March 2000 Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry

David H. Russell, Kent J. Gillig, Earle Stone, Zee-Yong Park, K. Fuhrer, M. Gonon, A. J. Schultz

Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380496
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Progress in the development of ion mobility (IM) orthogonal time-of-flight (oTOF) mass spectrometry for rapid analysis of biological samples is presented. The IM-oTOF apparatus described consists of a short drift tube (1 to 15 cm) designed for ion mobility measurement in the low-field limit and a low resolution linear (20 cm) TOF mass spectrometer. Proof of concept is demonstrated by analysis of peptide mixtures generated by proteolytic digestion of proteins.

Citation Download Citation

David H. Russell, Kent J. Gillig, Earle Stone, Zee-Yong Park, K. Fuhrer, M. Gonon, and A. J. Schultz "Protein mixture analysis by MALDI/mobility/time-of-flight mass spectrometry", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); https://doi.org/10.1117/12.380496

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available