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25 April 2000 Observation and analysis of microcirculation using high-spatial-resolution image detectors and synchrotron radiation
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Abstract
A microangiography system using monochromatized synchrotron radiation has been investigated as a diagnostic tool for circulatory disorders and early stage malignant tumors. The monochromatized X-rays with energies just above the contrast agent K-absorption edge energy can produce the highest contrast image of the contrast agent in small blood vessels. At SPring-8, digital microradiography with 6 - 24 micrometer pixel sizes has been carried out using two types of detectors designed for X-ray indirect and direct detection. The indirect-sensing detectors are fluorescent-screen optical-lens coupling systems using a high-sensitivity pickup-tube camera and a CCD camera. An X-ray image on the fluorescent screen is focused on the photoconductive layer of the pickup tube and the photosensitive area of the CCD by a small F number lens. The direct-sensing detector consists of an X-ray direct- sensing pickup tube with a beryllium faceplate for X-ray incidence to the photoconductive layer. Absorbed X-rays in the photoconductive layer are directly converted to photoelectrons and then signal charges are readout by electron beam scanning. The direct-sensing detector was expected to have higher spatial resolution in comparison with the indict-sensing detectors. Performance of the X-ray image detectors was examined at the bending magnet beamline BL20B2 using monochromatized X-ray at SPring-8. Image signals from the camera are converted into digital format by an analog-to- digital converter and stored in a frame memory with image format of 1024 X 1024 pixels. In preliminary experiments, tumor vessel specimens using barium contrast agent were prepared for taking static images. The growth pattern of tumor-induced vessels was clearly visualized. Heart muscle specimens were prepared for imaging of 3-dimensional microtomography using the fluorescent-screen CCD camera system. The complex structure of small blood vessels with diameters of 30 - 40 micrometer was visualized as a 3- dimensional CT image.
© (2000) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Keiji Umetani, Naoto Yagi, Yoshio Suzuki, Yasuo Ogasawara, Fumihiko Kajiya, Takeshi Matsumoto, Hiroyuki Tachibana, Masami Goto, Takenori Yamashita, Shigeki Imai, and Yasumasa Kajihara "Observation and analysis of microcirculation using high-spatial-resolution image detectors and synchrotron radiation", Proc. SPIE 3977, Medical Imaging 2000: Physics of Medical Imaging, (25 April 2000); https://doi.org/10.1117/12.384528
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