Development of a multispectral autoradiography using a coded aperture

Daisuke Noto; Tohoru Takeda; Jin Wu; Thet Thet Lwin; Quanwen Yu; Tsutomu Zeniya; Tetsuya Yuasa; Yukio Hiranaka; Yuji Itai; Takao Akatsuka

doi:10.1117/12.405842

2 November 2000 Development of a multispectral autoradiography using a coded aperture

Daisuke Noto, Tohoru Takeda, Jin Wu, Thet Thet Lwin, Quanwen Yu, Tsutomu Zeniya, Tetsuya Yuasa, Yukio Hiranaka, Yuji Itai, Takao Akatsuka

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Proceedings Volume 4113, Algorithms and Systems for Optical Information Processing IV; (2000) https://doi.org/10.1117/12.405842
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

Autoradiography is a useful imaging technique to understand biological functions using tracers including radio isotopes (RI's). However, it is not easy to describe the distribution of different kinds of tracers simultaneously by conventional autoradiography using X-ray film or Imaging plate. Each tracer describes each corresponding biological function. Therefore, if we can simultaneously estimate distribution of different kinds of tracer materials, the multispectral autoradiography must be a quite powerful tool to better understand physiological mechanisms of organs. So we are developing a system using a solid state detector (SSD) with high energy- resolution. Here, we introduce an imaging technique with a coded aperture to get spatial and spectral information more efficiently. In this paper, the imaging principle is described, and its validity and fundamental property are discussed by both simulation and phantom experiments with RI's such as ²⁰¹Tl, ^99mTc, ⁶⁷Ga, and ¹²³I.

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Daisuke Noto, Tohoru Takeda, Jin Wu, Thet Thet Lwin, Quanwen Yu, Tsutomu Zeniya, Tetsuya Yuasa, Yukio Hiranaka, Yuji Itai, and Takao Akatsuka "Development of a multispectral autoradiography using a coded aperture", Proc. SPIE 4113, Algorithms and Systems for Optical Information Processing IV, (2 November 2000); https://doi.org/10.1117/12.405842

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KEYWORDS

Coded apertures

Imaging systems

Monte Carlo methods

Collimators

Sensors

Spatial resolution

Coded aperture imaging

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