Ab-initio phasing in protein crystallography

J. L. van der Plas; Rick P. Millane

doi:10.1117/12.409276

16 November 2000 Ab-initio phasing in protein crystallography

J. L. van der Plas, Rick P. Millane

Proceedings Volume 4123, Image Reconstruction from Incomplete Data; (2000) https://doi.org/10.1117/12.409276
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

The central problem in the determination of protein structures form x-ray diffraction dada (x-ray crystallography) corresponds to a phase retrieval problem with undersampled amplitude data. Algorithms for this problem that have an increased radius of convergence have the potential for reducing the amount of experimental work, and cost, involved in determining protein structures. We describe such an algorithm. Application of the algorithm to a simulated crystallographic problem shows that it converges to the correct solution, with no initial phase information, where currently used algorithms fail. The results lend support to the possibility of ab initio phasing in protein crystallography.

Citation Download Citation

J. L. van der Plas and Rick P. Millane "Ab-initio phasing in protein crystallography", Proc. SPIE 4123, Image Reconstruction from Incomplete Data, (16 November 2000); https://doi.org/10.1117/12.409276

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