Application of 5-ALA for differential diagnostics of stomach diseases

Natalja L. Okhotnikova; Sergey A. Dadvany; Michail I. Kuszin; Sergey S. Kharnas; Victor Ya. Zavodnov; Olga A. Sklyanskaya; Victor B. Loschenov; Anna I. Volkova; Valery V. Agafonov

doi:10.1117/12.413712

31 January 2001 Application of 5-ALA for differential diagnostics of stomach diseases

Natalja L. Okhotnikova, Sergey A. Dadvany, Michail I. Kuszin, Sergey S. Kharnas, Victor Ya. Zavodnov, Olga A. Sklyanskaya, Victor B. Loschenov, Anna I. Volkova, Valery V. Agafonov

Author Affiliations +

Proceedings Volume 4156, Clinical Lasers and Diagnostics; (2001) https://doi.org/10.1117/12.413712
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

59 patients with stomach diseases including gastric cancer or polyp, gastritis, esofagus disease were investigated. Before gastroscopy all patients were given 5-ALA in doses 5mg, 10mg and 20mg per 1kg of body weight orally. Fluorescence diagnostics which estimates concentration of ALA-induced PPIX in regular and alternated tissues of gastric mucosa were carried out in 2-4 hours. Using of 5-ALA has shown high diagnostic effectiveness for differential diagnostics of stomach diseases. This technique has proved 10 diagnosis of cancer and revealed 15 malignant stomach diseases including 4 cancer in situ for patients with preliminary diagnosis of gastric ulcer. It also revealed 5 patients with enhanced fluorescence for which aimed biopsy has shown high degree of inflammation process. The latter were assigned as a risk group.

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Natalja L. Okhotnikova, Sergey A. Dadvany, Michail I. Kuszin, Sergey S. Kharnas, Victor Ya. Zavodnov, Olga A. Sklyanskaya, Victor B. Loschenov, Anna I. Volkova, and Valery V. Agafonov "Application of 5-ALA for differential diagnostics of stomach diseases", Proc. SPIE 4156, Clinical Lasers and Diagnostics, (31 January 2001); https://doi.org/10.1117/12.413712

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