Broadly tunable optical harmonic generation in type I collagen using IR nanosecond laser pulses

Theodossis Theodossiou; Efstratios Georgiou; Vladimir A. Hovhannisyan; Konstantine Politopoulos; Georgia Rapti; Dido M. Yova

doi:10.1117/12.409310

16 November 2000 Broadly tunable optical harmonic generation in type I collagen using IR nanosecond laser pulses

Theodossis Theodossiou, Efstratios Georgiou, Vladimir A. Hovhannisyan, Konstantine Politopoulos, Georgia Rapti, Dido M. Yova

Author Affiliations +

Proceedings Volume 4161, Optical Biopsy and Tissue Optics; (2000) https://doi.org/10.1117/12.409310
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Under pulsed nanosecond laser irradiation of type I pure collagen over the 760 - 1070 nm spectral range, optical up- conversion of the incident radiation is observed. More specifically irradiation of collagen at 1064, 901, 892, 828, 785 and 766 nm produces monochromatic second harmonic signals at half the original wavelengths i.e. 532, 451, 446, 414, 393 and 383 nm respectively. The dependence of the second harmonic signal on the excitation intensity was found to be quadratic [log(I₅₃₂) equals 1.92*log(I₁₀₆₄]. A weaker third harmonic signal was also observed from collagen at 355 nm when irradiated by 1064 nm nanosecond pulses. This signal was found to bear a near cubic dependence upon the irradiation intensity ]log(I₃₅₆) equals 2.53*log(I₁₀₆₄)]. The polar distribution of the second harmonic radiation was recorded for both pure fibrous collagen as well a for collagen diluted in acetic acid and forming a semitransparent dry film. In the latter case, significant optical behavior was demonstrated, potentially important for further studies of these nonlinear phenomena and for novel applications.

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Theodossis Theodossiou, Efstratios Georgiou, Vladimir A. Hovhannisyan, Konstantine Politopoulos, Georgia Rapti, and Dido M. Yova "Broadly tunable optical harmonic generation in type I collagen using IR nanosecond laser pulses", Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); https://doi.org/10.1117/12.409310

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