Novel cancer diagnostic method: FCLA-assisted sonodynamic diagnosis

Yonghong He; Da Xing; Yong Yao; Yonghong Tang; Shici Tan

doi:10.1117/12.405928

3 November 2000 Novel cancer diagnostic method: FCLA-assisted sonodynamic diagnosis

Yonghong He, Da Xing, Yong Yao, Yonghong Tang, Shici Tan

Proceedings Volume 4162, Controlling Tissue Optical Properties: Applications in Clinical Study; (2000) https://doi.org/10.1117/12.405928
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

In this paper, we propose, for the first time, the concept of Sono-Dynamic Diagnosis (SDD). The novel method named FCLA Assisted Sono-Dynamic Diagnosis is designed as follows: HpD is used to localize the cancer tissue, and is sonosensitized by the ultrasound field to produce singlet oxygen. Then, another reagent, FCLA (Fluoresceinyl Cypridina Luminescent Analog), reacts with O₂ to efficiently transform the chemical energy of O₂ to photons, thus a strong chemiluminescence is emitted. One can then detect this emission with a high sensitive CCD imaging system to localize the tumor. Based on the principle of FCLA assisted SDD, we obtained a clear diagnostic image of a transplanted tumor in a nude mouse in the experiments. It is shown that the emission from the tumor region is much stronger than that from other regions. The outline of the tumor is quite clear. This method could have potential applications in clinics for early-stage tumor diagnosis.

Citation Download Citation

Yonghong He, Da Xing, Yong Yao, Yonghong Tang, and Shici Tan "Novel cancer diagnostic method: FCLA-assisted sonodynamic diagnosis", Proc. SPIE 4162, Controlling Tissue Optical Properties: Applications in Clinical Study, (3 November 2000); https://doi.org/10.1117/12.405928

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