Trace drug analysis by surface-enhanced Raman spectroscopy

Stuart Farquharson; Vincent Yuan-Hsiang Lee

doi:10.1117/12.411716

29 December 2000 Trace drug analysis by surface-enhanced Raman spectroscopy

Stuart Farquharson, Vincent Yuan-Hsiang Lee

Proceedings Volume 4200, Biochemical and Biomolecular Sensing; (2000) https://doi.org/10.1117/12.411716
Event: Environmental and Industrial Sensing, 2000, Boston, MA, United States

Abstract

Drug overdose involves more than 10 percent of emergency room (ER) cases, and a method to rapidly identify and quantify the abused drug is critical to the ability of the ER physician to administer the appropriate care. To this end, we have been developing a surface-enhanced Raman (SER) active material capable of detecting target drugs at physiological concentrations in urine. The SER-active material consists of a metal-doped sol-gel that provides not only a million fold increase in sensitivity but also reproducible measurements. The porous silica network offers a unique environment for stabilizing SER active metal particles and the high surface area increase the interaction between the analyte and metal particles. The sol-gel has been coated on the inside walls of glass samples vials, such that urine specimens may simply be introduced for analysis. Here we present the surface-enhanced Raman spectra of a series of barbiturates, actual urine specimens, and a drug 'spiked' urine specimen. The utility of pH adjustment to suppress dominant biochemicals associated with urine is also presented.

Citation Download Citation

Stuart Farquharson and Vincent Yuan-Hsiang Lee "Trace drug analysis by surface-enhanced Raman spectroscopy", Proc. SPIE 4200, Biochemical and Biomolecular Sensing, (29 December 2000); https://doi.org/10.1117/12.411716

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