Effect of morphine on PC12 cells with molecular radar

Chen Shi; Xiaoli Yu; Jiuyi Lu; Chunyang Zhang; Lei Jin; Hui Ma; Dacheng Zhang; Die Yan Chen

doi:10.1117/12.403977

11 October 2000 Effect of morphine on PC12 cells with molecular radar

Chen Shi, Xiaoli Yu, Jiuyi Lu, Chunyang Zhang, Lei Jin, Hui Ma, Dacheng Zhang, Die Yan Chen

Proceedings Volume 4224, Biomedical Photonics and Optoelectronic Imaging; (2000) https://doi.org/10.1117/12.403977
Event: Optics and Optoelectronic Inspection and Control: Techniques, Applications, and Instruments, 2000, Beijing, China

Abstract

Molecular Radar (MR) is a new method to detect biological processes in living cells at the level of molecular, it is also the newest means to get intracellular information. In this paper we study the effect of morphine on PC12 cells using MR. The results show that the effect of morphine on PC12 cells is time- and concentration-dependent. Morphine treating for short time induces the increase and fluctuation of intracellular (CA²⁺), while morphine treating for long time induces chromatin condensation, loss of mitochondria membrane potential apoptosis.

Citation Download Citation

Chen Shi, Xiaoli Yu, Jiuyi Lu, Chunyang Zhang, Lei Jin, Hui Ma, Dacheng Zhang, and Die Yan Chen "Effect of morphine on PC12 cells with molecular radar", Proc. SPIE 4224, Biomedical Photonics and Optoelectronic Imaging, (11 October 2000); https://doi.org/10.1117/12.403977

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