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21 May 2001 Optical-coherence-reflectometry (OCR)-guided rf ablation guide wire for total occlusions
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Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001)
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States
One of the last remaining frontiers in angioplasty interventions is successfully recanalizing arteries containing total occlusions. The primary limitation is the inability to pass a guide wire safely across the total occlusion to facilitate therapeutic interventions, such as balloon angioplasty. The Optical Coherence Reflectometry (OCR) guide wire system has demonstrated clinical potential for navigating through total occlusions, but often these lesions are refractory to passage of the guide wire by mechanical force alone. The OCR guide wire has been coupled with low frequency (250-500 kHz), short duration (100 millisecond pulses) radio frequency energy to facilitate guided ablation through the total occlusion. Through a real- time monitoring system and display, the physician is warned if the guide wire approaches the normal arterial wall, allowing the guide wire to be redirected to prevent perforating the vessel. Coupled with the OCR guidance system, the RF ablation allows passage through highly resistant lesions that would not normally be transversed with conventional guide wires. The OCR guided RF guide wire system has been successfully tested in porcine models with cadaveric atherosclerotic diseased arterial grafts.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
John M. Neet, Thomas R. Winston M.D., Marlin R. Siglinger, Michael Janssen, and Ammon N. Balaster "Optical-coherence-reflectometry (OCR)-guided rf ablation guide wire for total occlusions", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001);

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