Using radiance predicted by the P3-approximation for treatment planning for PDT for prostatic carcinoma

Dwayne J. Dickey; Ronald B. Moore; David R. Rayner; John Tulip

doi:10.1117/12.424436

9 April 2001 Using radiance predicted by the P3-approximation for treatment planning for PDT for prostatic carcinoma

Dwayne J. Dickey, Ronald B. Moore, David R. Rayner, John Tulip

Proceedings Volume 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X; (2001) https://doi.org/10.1117/12.424436
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The P3-Approximation was used to optically characterize ex-vivo human prostate and to investigate the role that optical inhomogeneity, at the boundary between the prostate and its surrounding tissues, will play in tissue light dosimetry. Each prostate was found to be optically homogeneous, observing only slight variations in the scattering coefficient (o = 29 mm' to 34 mni'). Every prostate had the same absorption coefficients (o =0.08 mm') and anisotropy factors (g = 0.94). The variation in scattering coefficient had nearly inconsequential effects on theoretical fluence calculations, fluence being the key method of quantifying light for dosimetry purposes. To explore the boundary effects, a prostate was suspending above the bottom of a black painted bowl. Radiance measurements were taken and then intralipid was added until the prostate was completely submersed. The radiance measurements after the addition of intralipid varied greatly from the initial measurements without intralipid. An increase in light intensity was observed, as well as alteration in the shape of the radiance profile implying that surrounding tissues will have an effect on light transport. These must be characterized and integrated into a comprehensive light dosimetry model for PDT ofprostatic carcinoma.

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Dwayne J. Dickey, Ronald B. Moore, David R. Rayner, and John Tulip "Using radiance predicted by the P3-approximation for treatment planning for PDT for prostatic carcinoma", Proc. SPIE 4248, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy X, (9 April 2001); https://doi.org/10.1117/12.424436

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KEYWORDS

Prostate

Tissues

Tissue optics

Scattering

Photodynamic therapy

Light scattering

Sensors

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