3D simultaneous reconstruction of absorption and scattering coefficients in time-resolved optical tomography

Feng Gao; Patrick Poulet; Yukio Yamada

doi:10.1117/12.434526

29 June 2001 3D simultaneous reconstruction of absorption and scattering coefficients in time-resolved optical tomography

Feng Gao, Patrick Poulet, Yukio Yamada

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434526
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A Newton-Raphson inversion algorithm is extended for simultaneous absorption and scattering reconstruction of full 3-dimensional (3D) time-resolved diffuse optical tomography, which is based on efficient computation of Jacobian matrix of the forward model, and uses Algebraic Reconstruction Technique as the linear inversion tool. We validate the algorithm using both numerically simulated data from 3D finite-element discretization model of a tissue-like cylindrical phantom, embedding three inhomogeneities with different geometric and optical properties, as well as experimental measurements for a 3-D structural cylindrical phantom containing three absorptive rods, by means of fan-beam scanning mode. Our results show that a full 3D simultaneous reconstruction of absorption and scattering in turbid medium can be achieved with highly reasonable quality provided that the diffusive nature of light propagation in tissue is appropriately modeled, and temporal information of the measurements effectively employed.

Citation Download Citation

Feng Gao, Patrick Poulet, and Yukio Yamada "3D simultaneous reconstruction of absorption and scattering coefficients in time-resolved optical tomography", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434526

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