Optical tomography with early arriving photons: sensitivity and resolution analysis

Nanguang Chen; Quing Zhu

doi:10.1117/12.434507

29 June 2001 Optical tomography with early arriving photons: sensitivity and resolution analysis

Nanguang Chen, Quing Zhu

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434507
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Biological tissues are classified as turbid media to visible and near infrared lights. Photons propagating in tissue generally experience hundreds of scattering events before eventually being absorbed or escaping through boundaries. A lot of attention has been paid to exploiting diffusive photon density waves, which is, however, associated with difficulties in image reconstruction. Early arriving photons consist of a very small portion of photons reaching a detector. As they undergo forward scattering, their trajectories aggregate together to form a thin beam which probes limited volume. This makes it possible to implement single scanning scheme and to acquire more independent information for high quality images. This work is a preliminary theoretical study concerning the sensitivity and image resolution of a time-gating system. The Controlled Monte Carlo method was used for simulating migration of early arriving photons. Optical parameters and phantom dimensions were so chosen that they were applicable to breast cancer detection. Acquired edge-spread functions manifest the possibility of millimeter spatial resolution. Sensitivity analysis was derived from perturbations caused by targets of various contrasts and sizes, with respect to different temporal windows.

Citation Download Citation

Nanguang Chen and Quing Zhu "Optical tomography with early arriving photons: sensitivity and resolution analysis", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434507

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