Advanced development of the digital tuberculosis tester for MDR-TB screening

Jason E. Smith; Michelle D. Simkulet; Alexander Gutin; Alexy Gutin; Savco Bardarov; William R. Jacobs Jr.; James Castracane; Oliver Tang; Paul Riska

doi:10.1117/12.426753

22 May 2001 Advanced development of the digital tuberculosis tester for MDR-TB screening

Jason E. Smith, Michelle D. Simkulet, Alexander Gutin, Alexy Gutin, Savco Bardarov, William R. Jacobs Jr., James Castracane, Oliver Tang, Paul Riska

Author Affiliations +

Proceedings Volume 4255, Clinical Diagnostic Systems; (2001) https://doi.org/10.1117/12.426753
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease, and the threat is becoming more critical with the spread of multi-drug resistant Tuberculosis (MDR-TB). TB detection, and susceptibility testing for drug resistant strain identification, is advancing with the development of Luciferase Reporter Mycobacteriophages (LRM). LRM will emit visible light at very low intensity when in the presence of live mycobacteria cells such as Tuberculosis strains. InterScience, Inc., together with its collaboration, is developing a highly sensitive, real-time digital detection system for the analysis of luminescent assays. Recent advances in system sensitivity, design, and implementation, as well as preliminary results of the development of individual test cartridges, will be presented. The ultimate goal of this work is to provide a versatile luminescence detection tool for widespread research and clinical applications.

Citation Download Citation

Jason E. Smith, Michelle D. Simkulet, Alexander Gutin, Alexy Gutin, Savco Bardarov, William R. Jacobs Jr., James Castracane, Oliver Tang, and Paul Riska "Advanced development of the digital tuberculosis tester for MDR-TB screening", Proc. SPIE 4255, Clinical Diagnostic Systems, (22 May 2001); https://doi.org/10.1117/12.426753

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KEYWORDS

Imaging systems

Digital imaging

Cameras

Signal detection

Acquisition tracking and pointing

Luminescence

Optical testing

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