Near-infrared spectroscopic approach to assess tissue viability following a thermal injury

Lorenzo Leonardi; Michael G. Sowa; Jeri R. Payette; Mark D. Hewko; Bernhard J. Schattka; Anna Matas; Henry H. Mantsch

doi:10.1117/12.432478

2 July 2001 Near-infrared spectroscopic approach to assess tissue viability following a thermal injury

Lorenzo Leonardi, Michael G. Sowa, Jeri R. Payette, Mark D. Hewko, Bernhard J. Schattka, Anna Matas, Henry H. Mantsch

Proceedings Volume 4259, Biomarkers and Biological Spectral Imaging; (2001) https://doi.org/10.1117/12.432478
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

A recurrent problem in the assessment of thermal injuries is the ability to accurately identify the depth and extent of injury. Generally, the depth of a burn injury determines and is inversely related to the ability of the skin to restore and regenerate itself. Burns involve damage to the dermis in varying amounts, reducing the dermal blood supply and altering the skin hemodynamics. Near infrared spectroscopic imaging was used to non-invasively assess the changes that occur in the early (1-3 h) post-burn period. The study used an accurate porcine model to investigate the potential of near infrared spectroscopic imaging to accurately distinguish between burns of varying severity. Data analysis was carried out using a two-way and three-way data decompositions techniques to investigate the spectral changes related to burns. Burn injuries drastically alter the physical and optical properties of the tissue. Thermal destruction of cutaneous vasculature disrupts perfusion and oxygen delivery to the affected tissue. The results demonstrated that near infrared spectroscopic imaging might provide a new tool for an objective clinical assessment of burn injuries.

Citation Download Citation

Lorenzo Leonardi, Michael G. Sowa, Jeri R. Payette, Mark D. Hewko, Bernhard J. Schattka, Anna Matas, and Henry H. Mantsch "Near-infrared spectroscopic approach to assess tissue viability following a thermal injury", Proc. SPIE 4259, Biomarkers and Biological Spectral Imaging, (2 July 2001); https://doi.org/10.1117/12.432478

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