Improved detection of simulated thrombus by layer decomposition of coronary angiograms

Robert A. Close; Craig A. Morioka; Craig K. Abbey; James Stuart Whiting

doi:10.1117/12.431150

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3 July 2001 Improved detection of simulated thrombus by layer decomposition of coronary angiograms

Robert A. Close, Craig A. Morioka, Craig K. Abbey, James Stuart Whiting

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Proceedings Volume 4322, Medical Imaging 2001: Image Processing; (2001) https://doi.org/10.1117/12.431150
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

Layer decomposition is a promising technique for background removal and noise reduction in coronary angiograms. Our layer decomposition algorithm decomposes a projection image sequence into multiple 2D layers undergoing translation, rotation, and scaling. We apply this layer decomposition algorithm to simulated angiograms containing stenotic vessels with and without thrombus. We constructed 85 pairs of simulated angiographic sequences by embedding each of 5 simulated vessels (with and without thrombus) in 17 clinical angiograms. We computed the response of a matched eye filter applied to (1) one raw image of each sequence at the time of minimal motion (RAW), (2) a layered digital subtraction angiography (LDSA) image of the same frame, and (3) the time-averaged vessel layer image (LAYER). We find that on average the LAYER and LDSA images have higher signal-to-noise ration and larger area under the receiver- operator characteristic curves (AUC) than the raw images.

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Robert A. Close, Craig A. Morioka, Craig K. Abbey, and James Stuart Whiting "Improved detection of simulated thrombus by layer decomposition of coronary angiograms", Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); https://doi.org/10.1117/12.431150

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