Multicenter clinical trial using next-generation Internet technology

Mary-Lou Ingeholm; Betty A. Levine; Florian Eichler; Huacheng Tu; Gerardo Jimenez-Sanchez; Hugo Moser

doi:10.1117/12.435470

7 August 2001 Multicenter clinical trial using next-generation Internet technology

Mary-Lou Ingeholm, Betty A. Levine, Florian Eichler, Huacheng Tu, Gerardo Jimenez-Sanchez, Hugo Moser

Proceedings Volume 4323, Medical Imaging 2001: PACS and Integrated Medical Information Systems: Design and Evaluation; (2001) https://doi.org/10.1117/12.435470
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

The capacity to evaluate therapies in a multi-center clinical trial for a rare disease like X-linked adrenoleukodystrophy (ALD) can be improved by establishing a network for transmitting magnetic resonance imaging (MRI) data using current Internet and Next Generation Internet (NGI) technologies. A Digital Imaging and Communications in Medicine (DICOM) 3.0 application has been installed; it functions as a storage service class provider (SCP), query/retrieve SCP and central database. Sites with query/retrieve (Q/R) service class user (SCU) applications have access to the images. Using the DICOM Q/R SCU application, timing studies of image retrieval for a standard Internet connection and an NGI connection have been conducted. Standard Internet results indicate that performance is affected by bandwidth limitation and is constrained by network traffic, inhibiting the standard Internet as a useful tool for real-time therapy evaluation. NGI results indicate a higher and more consistent data throughput. The increased transmission speed along with the promise of improved quality of service offered by the NGI connection allows for physicians to discuss the images, correlate them with other disease findings, measure disease severity, and request additional MRI studies in real-time permitting a more efficient clinical evaluation strategy. The elimination of variability of transmission speed is no less significant, allowing the physicians to reserve the time needed for such consultations.

Citation Download Citation

Mary-Lou Ingeholm, Betty A. Levine, Florian Eichler, Huacheng Tu, Gerardo Jimenez-Sanchez, and Hugo Moser "Multicenter clinical trial using next-generation Internet technology", Proc. SPIE 4323, Medical Imaging 2001: PACS and Integrated Medical Information Systems: Design and Evaluation, (7 August 2001); https://doi.org/10.1117/12.435470

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KEYWORDS

Internet

Magnetic resonance imaging

Atomic layer deposition

Databases

Standards development

Therapeutics

Clinical trials

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