Optimization of real-time high-frequency ultrasound for blood flow imaging in the microcirculation

Dustin Edward Kruse; Jerome J. Mai; Ronald H. Silverman; Michael F. Insana; D. Jackson Coleman M.D.; Katherine W. Ferrara

doi:10.1117/12.428203

30 May 2001 Optimization of real-time high-frequency ultrasound for blood flow imaging in the microcirculation

Dustin Edward Kruse, Jerome J. Mai, Ronald H. Silverman, Michael F. Insana, D. Jackson Coleman M.D., Katherine W. Ferrara

Author Affiliations +

Proceedings Volume 4325, Medical Imaging 2001: Ultrasonic Imaging and Signal Processing; (2001) https://doi.org/10.1117/12.428203
Event: Medical Imaging 2001, 2001, San Diego, CA, United States

Abstract

The first high frequency ultrasound system able to image blood flow in the microcirculation in real-time has been developed. 2D color flow frames are rapidly acquired using a recently reported method to achieve frame rates approaching 10 fps. A new flow phantom was constructed in order to tune the wall filter order, cutoff and attenuation for a 25 MHz, f/2 transducer. RF data were acquired in both M-mode and swept-mode, and processed in order to tune the wall filter. These filters were then used in making controlled measurements of flow velocity and volume flow rate for a typical PRF of 500 Hz (1 mm/sec scan speed). Over th einput of mean axial velocities ranging from 0.3 to 3.0 mm/sec (0.88 to 8.8 mm/sec angle corrected), the measured mean and maximum flow velocities were linear, with slight over-estimation of mean velocities due to the wall filter cutoff. Without correction for finite beam size, the volume flow rates were over-estimated by a factor of 2. The color flow settings were then applied to image microcirculatory flow within the nail bed of a human finger, where they were tested and optimized for a variety of vessel sizes and flow velocities.

Citation Download Citation

Dustin Edward Kruse, Jerome J. Mai, Ronald H. Silverman, Michael F. Insana, D. Jackson Coleman M.D., and Katherine W. Ferrara "Optimization of real-time high-frequency ultrasound for blood flow imaging in the microcirculation", Proc. SPIE 4325, Medical Imaging 2001: Ultrasonic Imaging and Signal Processing, (30 May 2001); https://doi.org/10.1117/12.428203

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