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19 December 2001 Developments in CCD-based beta/x-ray imaging
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Abstract
A CCD imaging system has been developed for detecting and imaging the beta/X-ray emissions from radiolabelled samples, principally for use in autoradiography. By using a novel frame-by-frame acquisition method, quantitative images of 14C-deoxyglucose distribution in a mouse brain have been produced with a spatial resolution of ~35micrometers under cooled conditions. The energy resolution of the cooled device has been measured using X-rays from 241Am, and found to be 0.5keV at 17.5 keV. We describe the problems associated with using a CCD at room temperature for radiation detection and imaging. To address these we have developed a simple histogram shift for dark current fixed pattern noise. We have also developed an image restoration method based on simulated annealing using CCD-specific models for the noise and the data. Applying both techniques to images of 20micrometers 18F labeled fibers obtained at room temperature yields FWHM measurements of ~85micrometers and ~39micrometers respectively.
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Kevin Wells, Eleni Kokkinou, Maria Petrou, A. Ranicar, T. Spinks, and Robert J. Ott "Developments in CCD-based beta/x-ray imaging", Proc. SPIE 4508, Penetrating Radiation Systems and Applications III, (19 December 2001); https://doi.org/10.1117/12.450777
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