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19 December 2001 Developments in CCD-based beta/x-ray imaging
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A CCD imaging system has been developed for detecting and imaging the beta/X-ray emissions from radiolabelled samples, principally for use in autoradiography. By using a novel frame-by-frame acquisition method, quantitative images of 14C-deoxyglucose distribution in a mouse brain have been produced with a spatial resolution of ~35micrometers under cooled conditions. The energy resolution of the cooled device has been measured using X-rays from 241Am, and found to be 0.5keV at 17.5 keV. We describe the problems associated with using a CCD at room temperature for radiation detection and imaging. To address these we have developed a simple histogram shift for dark current fixed pattern noise. We have also developed an image restoration method based on simulated annealing using CCD-specific models for the noise and the data. Applying both techniques to images of 20micrometers 18F labeled fibers obtained at room temperature yields FWHM measurements of ~85micrometers and ~39micrometers respectively.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kevin Wells, Eleni Kokkinou, Maria Petrou, A. Ranicar, T. Spinks, and Robert J. Ott "Developments in CCD-based beta/x-ray imaging", Proc. SPIE 4508, Penetrating Radiation Systems and Applications III, (19 December 2001);

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