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23 October 2001 Approach to sequence DNA without tagging
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Proceedings Volume 4512, Complex Adaptive Structures; (2001) https://doi.org/10.1117/12.446773
Event: Complex Adaptive Structures, 2001, Hutchinson Island, FL, United States
Abstract
A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.
© (2001) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Sanjun Niu and Ravi F. Saraf "Approach to sequence DNA without tagging", Proc. SPIE 4512, Complex Adaptive Structures, (23 October 2001); https://doi.org/10.1117/12.446773
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