Monitoring of tissue modification with optical coherence tomography

Wei Zhang; Qingming Luo; Lei Yao; Haiying Cheng; Shaoqun Zeng

doi:10.1117/12.462560

12 April 2002 Monitoring of tissue modification with optical coherence tomography

Wei Zhang, Qingming Luo, Lei Yao, Haiying Cheng, Shaoqun Zeng

Proceedings Volume 4536, International Workshop on Photonics and Imaging in Biology and Medicine; (2002) https://doi.org/10.1117/12.462560
Event: International Workshop on Photonics and Imaging in Biology and Medicine, 2001, Wuhan, China

Abstract

An experimental monitoring of tissue modification of in vitro and in vivo rabbit dura mater with administration of osmotical agents, 40% glucose solution and glycerol, using optical coherence tomography was presented. The preliminary results of experimental study of influence of osmotical liquids (glucose solutions, glycerol) of rabbit dura mater were reported. The significant decreasing of the light from surface and increasing of the light from the deep of dura mater under action of osmotical solutions and the increasing of OCT imaging depth were demonstrated. Experiments showed that administration of osmolytes to dura mater allowed for effective and temporary control of its optical characteristics, which made dura mater more transparent, increased the ability of light penetrating the tissue, and consequently improved the optical imaging depth. It is a significant study, which can improve penetration of optical imaging of cerebral function and acquire more information of the deep brain tissue.

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Wei Zhang, Qingming Luo, Lei Yao, Haiying Cheng, and Shaoqun Zeng "Monitoring of tissue modification with optical coherence tomography", Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); https://doi.org/10.1117/12.462560

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KEYWORDS

Tissue optics

Optical coherence tomography

Glucose

Optical imaging

Biology

In vitro testing

In vivo imaging

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