Laser-induced photodynamic effect

Hana Kolarova; Roman Kubinek; Leos Navratil; Miroslav Strnad; Kamila Reblova; Jiri Skopek

doi:10.1117/12.446710

23 October 2001 Laser-induced photodynamic effect

Hana Kolarova, Roman Kubinek, Leos Navratil, Miroslav Strnad, Kamila Reblova, Jiri Skopek

Proceedings Volume 4606, Laser Florence 2000: A Window on the Laser Medicine World; (2001) https://doi.org/10.1117/12.446710
Event: Laser Florence 2000: A Window on the Laser Medicine World, 2000, Florence, Italy

Abstract

Photodynamic therapy is a treatment that is used for destruction of certain tumors. The treatment is performed with photosensitizers that generate reactive oxygen species in the presence of light and oxygen. The absorption and fluorescence spectra of the ClAlPcS₂ and ZnPcS₂ photosensitizers were measured. From this analysis a semiconductor laser emitting a beam of 50 mW cw power at the wavelength of 675 nm for our experiments was chosen, because this wavelength corresponded with the absorption maximum (675 nm) in long-wave region of the visible part of electromagnetic spectra. B16 (cells line of mouse melanoma) was chosen as a standard testing system for definition of the in vitro phototoxicity after photodynamic reaction. The optimal phototoxic effect on B16 cells was observed at 2 (mu) g/ml ClAlPcS₂ in combination with laser irradiation of 10 J/cm².

Citation Download Citation

Hana Kolarova, Roman Kubinek, Leos Navratil, Miroslav Strnad, Kamila Reblova, and Jiri Skopek "Laser-induced photodynamic effect", Proc. SPIE 4606, Laser Florence 2000: A Window on the Laser Medicine World, (23 October 2001); https://doi.org/10.1117/12.446710

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