Clinical trials of a new chlorin photosensitizer for photodynamic therapy of malignant tumors

Valeriy A. Privalov; Alexander V. Lappa; Oleg V. Seliverstov; Alexey B. Faizrakhmanov; Nicolay N. Yarovoy; Elena V. Kochneva; Michail V. Evnevich; Alla S. Anikina; Andrey V. Reshetnicov; Igor Dmitrievich Zalevsky; Yuriy V. Kemov

doi:10.1117/12.469355

6 June 2002 Clinical trials of a new chlorin photosensitizer for photodynamic therapy of malignant tumors

Valeriy A. Privalov, Alexander V. Lappa, Oleg V. Seliverstov, Alexey B. Faizrakhmanov, Nicolay N. Yarovoy, Elena V. Kochneva, Michail V. Evnevich, Alla S. Anikina, Andrey V. Reshetnicov, Igor Dmitrievich Zalevsky, Yuriy V. Kemov

Author Affiliations +

Proceedings Volume 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI; (2002) https://doi.org/10.1117/12.469355
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) was performed with a new photosensitizer, a water soluble form of chlorins (Radachlorin, Russia) possessing an absorption peak around 662 nm. As light source there was used the diode laser (ML-662-SP, Russia) with 662 nm wavelength and 2.5 W optical power. The sensitizer had passed broad pre-clinical in vitro and in vivo studies, which showed safety and efficiency of it. PDT was applied to 51 patients with basal cell cancer of the skin (about 60% of all cases), breast cancer, lip cancer, melanoma, cancer of esophagus, stomach, and rectum, cancer and leucoplacia of vulva, malignant ganglioneuroma, sarcoma of soft tissue, cancer and reticular sarcoma of thyroid gland, cancer of ductus choledochus. Most of non-basalioma patients had either forth stage or recurrence of disease. The sensitizer was injected intravenously or applied externally (Radachlorin gel). There were used surface, endoscopic, and interstitial ways of irradiation. Full tumor regression with excellent cosmetic effect was reached in 100% cases of 1-3 stage basal cell cancer patients treated with intravenous Radachlorin injection. In most other (non-basalioma) cases significant regression of tumors and improvement of life quality of patients (recanalization and regain of conductivity) was obtained.

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Valeriy A. Privalov, Alexander V. Lappa, Oleg V. Seliverstov, Alexey B. Faizrakhmanov, Nicolay N. Yarovoy, Elena V. Kochneva, Michail V. Evnevich, Alla S. Anikina, Andrey V. Reshetnicov, Igor Dmitrievich Zalevsky, and Yuriy V. Kemov "Clinical trials of a new chlorin photosensitizer for photodynamic therapy of malignant tumors", Proc. SPIE 4612, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XI, (6 June 2002); https://doi.org/10.1117/12.469355

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