Determination of optical properties in highly attenuating media with an endoscope-compatible reflectance approach

T. Joshua Pfefer; L. Stephanie Matchette; Carrie L. Bennett; Joy A. Wilke; Anthony Joseph Durkin; Marwood N. Ediger

doi:10.1117/12.465248

1 May 2002 Determination of optical properties in highly attenuating media with an endoscope-compatible reflectance approach

T. Joshua Pfefer, L. Stephanie Matchette, Carrie L. Bennett, Joy A. Wilke, Anthony Joseph Durkin, Marwood N. Ediger

Author Affiliations +

Proceedings Volume 4613, Optical Biopsy IV; (2002) https://doi.org/10.1117/12.465248
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Accurate in vivo optical property data in the ultraviolet to visible range are scarce for many endoscope-accessible organs, yet such information is essential for understanding light propagation and identifying dosimetry standards for biomedical optical spectroscopy. We have performed a preliminary study towards the development of a reflectance-based system for endoscopic measurement of tissue optical properties relevant to fluorescence spectroscopy. To address the constraint of instrument channel diameter and strong attenuation of light in the spectral region of interest, maximum fiber separation distance was limited to 2.5 mm. Measurements were performed on tissue phantoms for a range of optical properties relevant to gastrointestinal mucosal tissues in the ultraviolet to visible range: absorption coefficients from 1 to 25 cm^-1 and reduced scattering coefficients from 5 to 25 cm^-1. Neural network and partial least squares algorithms were trained on radial reflectance profiles generated by a Monte Carlo model as well as by experimental data. These routines were then used to estimate absorption and reduced scattering coefficients from reflectance data. Results are discussed in terms of the optimization of models for optical property determination.

Citation Download Citation

T. Joshua Pfefer, L. Stephanie Matchette, Carrie L. Bennett, Joy A. Wilke, Anthony Joseph Durkin, and Marwood N. Ediger "Determination of optical properties in highly attenuating media with an endoscope-compatible reflectance approach", Proc. SPIE 4613, Optical Biopsy IV, (1 May 2002); https://doi.org/10.1117/12.465248

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