High-resolution optical coherence tomography with fiber-induced broadband source and process algorithm for oral cancer study

I-Jen Hsu; Chih-Wei Lu; Chih Chung Yang; Jun-Ping Chiang; Chii-Wann Lin

doi:10.1117/12.470467

14 June 2002 High-resolution optical coherence tomography with fiber-induced broadband source and process algorithm for oral cancer study

I-Jen Hsu, Chih-Wei Lu, Chih Chung Yang, Jun-Ping Chiang, Chii-Wann Lin

Author Affiliations +

Proceedings Volume 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI; (2002) https://doi.org/10.1117/12.470467
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

A polarization controllable optical coherence tomography (OCT) system was built with the broadband source generated with femtosecond Ti:sapphire laser pulses in fiber. Spectral broadening in such fiber originated from self-phase modulation, four-wave mixing, Raman scattering, and other nonlinear-optics effects. Two different mode-locked Ti:sapphire lasers with 100 fsec and 12 fsec pulses were used. The generated spectral shape and width were compared in terms of the application to the OCT system. The relationship between the OCT resolution and the source spectrum shape was studied. Also, an algorithm was built for increasing the effective longitudinal resolution in data processing. The scheme of this algorithm meant to separate the contribution of the central portion from those of the tails in the interference fringe envelope. By removing the tail contribution to the scanning results, the effective longitudinal resolution was improved. Such a procedure is particularly important when the light source spectrum is not a well-defined shape. This procedure involved in the computation of a matrix inversion. The OCT system and the process algorithm were used for oral cancer study. Features of oral cancer were well identified. A probe was also fabricated for in vivo scan of oral tissues.

Citation Download Citation

I-Jen Hsu, Chih-Wei Lu, Chih Chung Yang, Jun-Ping Chiang, and Chii-Wann Lin "High-resolution optical coherence tomography with fiber-induced broadband source and process algorithm for oral cancer study", Proc. SPIE 4619, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications VI, (14 June 2002); https://doi.org/10.1117/12.470467

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