Clinical results from a noninvasive blood glucose monitor

Thomas B. Blank; Timothy L. Ruchti; Alex D. Lorenz; Stephen L. Monfre; M. R. Makarewicz; Mutua Mattu; Kevin Hazen

doi:10.1117/12.468309

23 May 2002 Clinical results from a noninvasive blood glucose monitor

Thomas B. Blank, Timothy L. Ruchti, Alex D. Lorenz, Stephen L. Monfre, M. R. Makarewicz, Mutua Mattu, Kevin Hazen

Proceedings Volume 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II; (2002) https://doi.org/10.1117/12.468309
Event: International Symposium on Biomedical Optics, 2002, San Jose, CA, United States

Abstract

Non-invasive blood glucose monitoring has long been proposed as a means for advancing the management of diabetes through increased measurement and control. The use of a near-infrared, NIR, spectroscopy based methodology for noninvasive monitoring has been pursued by a number of groups. The accuracy of the NIR measurement technology is limited by challenges related to the instrumentation, the heterogeneity and time-variant nature of skin tissue, and the complexity of the calibration methodology. In this work, we discuss results from a clinical study that targeted the evaluation of individual calibrations for each subject based on a series of controlled calibration visits. While the customization of the calibrations to individuals was intended to reduce model complexity, the extensive requirements for each individual set of calibration data were difficult to achieve and required several days of measurement. Through the careful selection of a small subset of data from all samples collected on the 138 study participants in a previous study, we have developed a methodology for applying a single standard calibration to multiple persons. The standard calibrations have been applied to a plurality of individuals and shown to be persistent over periods greater than 24 weeks.

Citation Download Citation

Thomas B. Blank, Timothy L. Ruchti, Alex D. Lorenz, Stephen L. Monfre, M. R. Makarewicz, Mutua Mattu, and Kevin Hazen "Clinical results from a noninvasive blood glucose monitor", Proc. SPIE 4624, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring II, (23 May 2002); https://doi.org/10.1117/12.468309

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