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3 May 2002 Numerical environment for simulating 3D angiographic imaging of the coronary arteries
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A realistic numerical environment for simulating three-dimensional (3D) angiographic imaging of the coronary arteries has been developed. Through numerical simulation we propose to optimize acquisition and gating strategies, aiding in the design of 3D coronary imaging systems. We have previously developed a dynamic model of the coronary arteries, based on a high-resolution 3D image of an excised human heart, which was perfused with iodinated contrast agent. To mimic the motion of the arteries during the cardiac cycle, the motion of the vessel branch points was determined from cine bi-plane coronary angiograms of a patient with vessel anatomy similar to the excised heart. The static image was then non-linearly deformed to produce a sequence of volumetric images, with isotropic 0.4-mm resolution, representing the motion of the coronary arteries throughout the cardiac cycle. To simulate different acquisition strategies we have developed an algorithm to forward project through the volume data sets. The geometry of the CT system used to acquire the original 3D image of the static heart is mimicked in the re-projection algorithm. Thus, prospective radiographic projections corresponding to any projection-angle can be produced for any time -point throughout the cardiac cycle. Combining re-projections from selected time-points and view angles enables the evaluation of various acquisition and gating strategies.
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Glen Lehmann, Damiaan F. Habets, David W. Holdsworth, and Maria Drangova "Numerical environment for simulating 3D angiographic imaging of the coronary arteries", Proc. SPIE 4682, Medical Imaging 2002: Physics of Medical Imaging, (3 May 2002);

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