Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography

Julia Anne Schnabel; Christine Tanner; Andrew D. Castellano-Smith; Andreas Degenhard; Carmel Hayes; Martin O. Leach; D. Rodney Hose; Derek L.G. Hill; David John Hawkes

doi:10.1117/12.467197

9 May 2002 Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography

Julia Anne Schnabel, Christine Tanner, Andrew D. Castellano-Smith, Andreas Degenhard, Carmel Hayes, Martin O. Leach, D. Rodney Hose, Derek L.G. Hill, David John Hawkes

Author Affiliations +

Proceedings Volume 4684, Medical Imaging 2002: Image Processing; (2002) https://doi.org/10.1117/12.467197
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

This work presents a validation study for non-rigid registration of 3D contrast enhanced magnetic resonance mammography images. We are using our previously developed methodology for simulating physically plausible, biomechanical tissue deformations using finite element methods to compare two non-rigid registration algorithms based on single-level and multi-level free-form deformations using B-splines and normalized mutual information. We have constructed four patient-specific finite element models and applied the solutions to the original post-contrast scans of the patients, simulating tissue deformation between image acquisitions. The original image pairs were registered to the FEM-deformed post-contrast images using different free-form deformation mesh resolutions. The target registration error was computed for each experiment with respect to the simulated gold standard on a voxel basis. Registration error and single-level free-form deformation resolution were found to be intrinsically related: the smaller the spacing, the higher localized errors, indicating local registration failure. For multi-level free-form deformations, the registration errors improved for increasing mesh resolution. This study forms an important milestone in making our non-rigid registration framework applicable for clinical routine use.

Citation Download Citation

Julia Anne Schnabel, Christine Tanner, Andrew D. Castellano-Smith, Andreas Degenhard, Carmel Hayes, Martin O. Leach, D. Rodney Hose, Derek L.G. Hill, and David John Hawkes "Finite-element based validation of nonrigid registration using single- and multilevel free-form deformations: application to contrast-enhanced MR mammography", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); https://doi.org/10.1117/12.467197

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available