Method for quantitative assessment of atherosclerotic lesion burden on the basis of high-resolution black-blood MRI

Jeffrey Duda; Hee Kwon Song; Ronald Wolf M.D.; Alex Wright; James C. Gee; Felix W. Wehrli

doi:10.1117/12.467154

9 May 2002 Method for quantitative assessment of atherosclerotic lesion burden on the basis of high-resolution black-blood MRI

Jeffrey Duda, Hee Kwon Song, Ronald Wolf M.D., Alex Wright, James C. Gee, Felix W. Wehrli

Author Affiliations +

Proceedings Volume 4684, Medical Imaging 2002: Image Processing; (2002) https://doi.org/10.1117/12.467154
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

The aim of this work was to develop a reliable semi-automatic method for quantifying carotid atherosclerotic lesion burden using black-blood high-resolution MR images. Vessel wall volume was quantified by measuring its cross-sectional area in adjacent slices. Two methods for obtaining this measure are presented. The first method approximates the outer boundary of the vessel on a slice-by-slice basis by fitting an ellipse to user-identified points and automatically identifying the lumen through examination of the histogram obtained from a local region of interest (ROI). The second, method identifies the lumen and wall throughout the entire volume based upon user-selected points in a single slice. Radially directed intensity profiles are examined in order to automatically locate points on the outer boundary, and the same histogram-based method is used for lumen delineation. The measure of wall area provided by the manual outer boundary selection has an intra-class correlation coefficient (ICC) of 0.83 for test-retest comparisons, but the ICC values for the inter-observer comparisons (0.84, 0.65) suggest that user bias remains a potential source of error. A susceptibility to low image signal-to-noise ratio (SNR) may present a limitation on the usefulness of the automated outer boundary selection method for use on whole image volumes.

Citation Download Citation

Jeffrey Duda, Hee Kwon Song, Ronald Wolf M.D., Alex Wright, James C. Gee, and Felix W. Wehrli "Method for quantitative assessment of atherosclerotic lesion burden on the basis of high-resolution black-blood MRI", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); https://doi.org/10.1117/12.467154

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
9 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Arteries

Magnetic resonance imaging

Signal to noise ratio

Image processing

Scanning electron microscopy

Tissues

Image segmentation

Show All Keywords

Keywords/Phrases

Search In:

Publication Years