Quantitative MR assessment of longitudinal parenchymal changes in children treated for medulloblastoma

Wilburn E. Reddick; John O. Glass; Shingjie Wu; Shawna L. Palmer; Raymond K. Mulhern; Amar Gajjar

doi:10.1117/12.467208

9 May 2002 Quantitative MR assessment of longitudinal parenchymal changes in children treated for medulloblastoma

Wilburn E. Reddick, John O. Glass, Shingjie Wu, Shawna L. Palmer, Raymond K. Mulhern, Amar Gajjar

Author Affiliations +

Proceedings Volume 4684, Medical Imaging 2002: Image Processing; (2002) https://doi.org/10.1117/12.467208
Event: Medical Imaging 2002, 2002, San Diego, California, United States

Abstract

Our research builds on the hypothesis that white matter damage, in children treated for cancer with cranial spinal irradiation, spans a continuum of severity that can be reliably probed using non-invasive MR technology and results in potentially debilitating neurological and neuropsychological problems. This longitudinal project focuses on 341 quantitative volumetric MR examinations from 58 children treated for medulloblastoma (MB) with cranial irradiation (CRT) of 35-40 Gy. Quadratic mixed effects models were used to fit changes in tissue volumes (white matter, gray matter, CSF, and cerebral) with time since CRT and age at CRT as covariates. We successfully defined algorithms that are useful in the prediction of brain development among children treated for MB.

Citation Download Citation

Wilburn E. Reddick, John O. Glass, Shingjie Wu, Shawna L. Palmer, Raymond K. Mulhern, and Amar Gajjar "Quantitative MR assessment of longitudinal parenchymal changes in children treated for medulloblastoma", Proc. SPIE 4684, Medical Imaging 2002: Image Processing, (9 May 2002); https://doi.org/10.1117/12.467208

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