Emissive spectral analysis applied in 15N excretion test of Helicobacter pylori

Yayi Zhu; Jicong Wu; Zhenhua Zhang

doi:10.1117/12.482949

12 September 2002 Emissive spectral analysis applied in ¹⁵N excretion test of Helicobacter pylori

Yayi Zhu, Jicong Wu, Zhenhua Zhang

Proceedings Volume 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment; (2002) https://doi.org/10.1117/12.482949
Event: Photonics Asia, 2002, Shanghai, China

Abstract

A new method for detecting the infection of Helicobacter pylon (HP), '5N-urea tracing and emissive optical spectroscopy method, is described in this paper. A group of 26 patients was tested. After '5N-urea was administered orally, urine specimen was collected from 30 to 120 minutes and its volume was measured. Then the concentration of ammonia in the urine specimen was determined. A special emissive optical spectrometer was applied to measure the '5N-abundance ofthe urine specimen, which was designed and manufactured by us and was an intelligent system. It contains a monochromator, a high frequency generator, a precise amplifier and a computer. The ratio (R) of the 15N amount of excretion in the urine to that of ingestion was found out. HP positive infection was predicated if R>0.3%. Taking the bacterial culture or (and) Gram stain as a reference standard, the specificity, sensitivity and positive predictability ofour test were 81%, 89% and 84% respectively. The new method is sensitive, noninvasive and useful for clinical practice. It is worth studying it further.

Citation Download Citation

Yayi Zhu, Jicong Wu, and Zhenhua Zhang "Emissive spectral analysis applied in ¹⁵N excretion test of Helicobacter pylori", Proc. SPIE 4916, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment, (12 September 2002); https://doi.org/10.1117/12.482949

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