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14 November 2002 Evaluation of the MOSFET type biosensor using glucose oxidase
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A lot of researches and developments of medical device based on micromechatronics are performed. We develop the glucose sensor for using at HMS (Health Monitoring System) as one of the devices of those. In the development of a glucose sensor, it is necessary that the efficient hybridization between enzyme (glucose oxidase : GOD) as receptor and semiconductor as transducer. We devised the biosensor which used GOD immobilized gold plate as a gate electrode of the MOSFET. By utilizing this type, it becomes possible that the sensor part is easily miniaturized. When the glucose was detected using this sensor, there was a signal with concentration dependence. Therefore, it was confirmed that the prototype glucose sensor operated as a biosensor. From the above results, MOSFET type biosensor with gate electrode which immobilized GOD produced in this paper seems to be enough available as a glucose sensor. For miniaturization of the system, we examined the relationship between size of the working electrode and detection sensitivity. Consideration of the electrode area was not needed to detect the signal sensitively from the glucose sensor. And when we changed glass reference electrode to Au electrode, the enough sensitivity was obtained, too.
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Katsutoshi Ooe, Yasutaro Hamamoto, Tadashi Iuchi, and Yoshiaki Hirano "Evaluation of the MOSFET type biosensor using glucose oxidase", Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002);

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