New experimental analysis method clarifies spectral threshold of laser ocular bioeffects

Amir Langus; Camil Fuchs; Israel Gannot

doi:10.1117/12.476865

20 June 2003 New experimental analysis method clarifies spectral threshold of laser ocular bioeffects

Amir Langus, Camil Fuchs, Israel Gannot

Proceedings Volume 4953, Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III; (2003) https://doi.org/10.1117/12.476865
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

For more than 10 years there have been discussions regarding the unexplainable significant variation of the ED50 attained with small changes in wavelength, found in the experimental results reported by the USAMRD-WRAIR. Previous studies showed that the probit analysis that was used to estimate the ED₅₀ occasionally yield unreliable results in the special case of data gathered in dose-respond laser-tissue experiment. A reanalysis the data of the USAMRD-WRAIR revealed significant subject’s dissimilarity that was not considered in the first analysis. However, though both the subjects dissimilarity and the potential of unreliable probit’s estimates could contribute to the spectral ED₅₀ variation, no satisfying analysis and expiation of spectral ED₅₀ has yet been suggested. A new analysis method that inherently incorporates physical and statistical models will be presented. This method enables the identification of the laser damage mechanism and suggests a new spectral ED₅₀. The method can, then, also disclose questionable data sections, which neither complies with the data majority nor follows physical causality.

Citation Download Citation

Amir Langus, Camil Fuchs, and Israel Gannot "New experimental analysis method clarifies spectral threshold of laser ocular bioeffects", Proc. SPIE 4953, Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III, (20 June 2003); https://doi.org/10.1117/12.476865

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