Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

Yueqing Gu; Vincent Bourke; Jae Gwan Kim; Mengna Xia; Anca Constantinescu; Ralph P. Mason; Hanli Liu

doi:10.1117/12.479465

29 July 2003 Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters

Yueqing Gu, Vincent Bourke, Jae Gwan Kim, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Author Affiliations +

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.479465
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO₂, tumor vascular oxygenated hemoglobin concentration [HbO₂], and tumor oxygen tension pO₂) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY) to evaluate dynamic responses of breast tumors to carbogen (5% CO₂ and 95% O₂) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO₂, followed by changes in global tumor vascular [HbO₂], and delayed responses for pO₂. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.

Citation Download Citation

Yueqing Gu, Vincent Bourke, Jae Gwan Kim, Mengna Xia, Anca Constantinescu, Ralph P. Mason, and Hanli Liu "Breast tumor oxygenation in response to carbogen intervention assessed simultaneously by three oxygen-sensitive parameters", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.479465

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