Signal source separation and localization in the analysis of dynamic near-infrared optical tomographic time series

Harry L. Graber; Yaling Pei; Randall Locke Barbour; David K. Johnston; Ying Zheng; John E. Mayhew

doi:10.1117/12.479467

29 July 2003 Signal source separation and localization in the analysis of dynamic near-infrared optical tomographic time series

Harry L. Graber, Yaling Pei, Randall Locke Barbour, David K. Johnston, Ying Zheng, John E. Mayhew

Author Affiliations +

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.479467
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The emerging sub-field of dynamic medical optical tomography shows great potential for conferring significantly enhanced early diagnosis and treatment monitoring capabilities upon researchers and clinicians. In previous reports we have showed that adoption of elementary time-series analysis techniques can bring about large large improvements in localization and contrast in optical tomographic images. Here we build upon the earlier work, and show that well-known techniques for extraction and localization of signals embedded in a noisy background, and for deconvolution of signal mixtures, also can be successfully applied to the problem of interpreting dynamic optical tomography data sets. A general linear model computation is used for the signal extraction/localization problem, while the deconvolution problem is addressed by means of a blind source separation technique extensively reported.

Citation Download Citation

Harry L. Graber, Yaling Pei, Randall Locke Barbour, David K. Johnston, Ying Zheng, and John E. Mayhew "Signal source separation and localization in the analysis of dynamic near-infrared optical tomographic time series", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.479467

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