Fluorescence and reflectance monitoring of human cervical tissue in vivo: a case study

Ulf P. Gustafsson; Elisabeth McLaughlin; Ellen Jacobson; Johan Håkansson; Paul Troy; Michael James DeWeert; Sara Pålsson II; Marcelo Soto Thompson; Sune Svanberg; Aurelija Vatkuviene; Katarina Svanberg

doi:10.1117/12.479495

2 July 2003 Fluorescence and reflectance monitoring of human cervical tissue in vivo: a case study

Ulf P. Gustafsson, Elisabeth McLaughlin, Ellen Jacobson, Johan Håkansson, Paul Troy, Michael James DeWeert, Sara Pålsson II, Marcelo Soto Thompson, Sune Svanberg, Aurelija Vatkuviene, Katarina Svanberg

Author Affiliations +

Proceedings Volume 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II; (2003) https://doi.org/10.1117/12.479495
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

An imaging spectrograph, designed and built by Science and Technology International (STI), and a point monitoring system, developed at the Lund Institute of Technology, have been used to measure the fluorescence and reflectance of cervical tissue in vivo. The instruments have been employed in a clinical trial in Vilnius, Lithuania, where 111 patients were examined. Patients were initially screened by Pap smear, examined by colposcopy and a tissue sampling procedure was performed. Detailed histopathological assessments were performed on the biopsies, and these assessments were correlated with spectra and images. The results of the spectroscopic investigations are illustrated by a thorough discussion of a case study for one of the patients, suggesting that the techniques are useful in the management of cervical malignancies.

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Ulf P. Gustafsson, Elisabeth McLaughlin, Ellen Jacobson, Johan Håkansson, Paul Troy, Michael James DeWeert, Sara Pålsson II, Marcelo Soto Thompson, Sune Svanberg, Aurelija Vatkuviene, and Katarina Svanberg "Fluorescence and reflectance monitoring of human cervical tissue in vivo: a case study", Proc. SPIE 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II, (2 July 2003); https://doi.org/10.1117/12.479495

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