Detection of prostate cancer with optoacoustic tomography: feasibility and modeling

Valeri G. Andreev; Anatoly E. Ponomarev; P. Mark Henrichs; Massoud Motamedi; Eduardo Orihuela M.D.; Eduardo Eyzaguirre; Alexander A. Oraevsky

doi:10.1117/12.483489

1 July 2003 Detection of prostate cancer with opto-acoustic tomography

Valeri G. Andreev, Anatoly E. Ponomarev, P. Mark Henrichs, Massoud Motamedi, Eduardo Orihuela M.D., Eduardo Eyzaguirre, Alexander A. Oraevsky

Author Affiliations +

Proceedings Volume 4960, Biomedical Optoacoustics IV; (2003) https://doi.org/10.1117/12.483489
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

The laser optoacoustic imaging system (LOIS) for prostate cancer detection, localization and characterization with 32-element transducer array was developed and tested. Each transducer was made of 50-μm thick PVDF film with dimensions of 1mm x 10 mm. The thickness of the PVDF film allowed 100-μm axial in-depth resolution. Cylindrical shape of the 5-cm long transducer array provided an improved lateral resolution of 0.35 mm. Original design of low noise preamplifiers and wide band amplifiers was employed. The system was optimized for contrast and sensitivity. An automatic recognition of the opto-acoustic signal detected from the irradiated surface was implemented in order to visualize the prostate surface and improve the accuracy of tumor localization. Radial back-projection algorithm adopting Radon transform was used for image reconstruction. The advantages and limitations various contrast enhancing filters applied to the whole image were studied and discussed. Images were acquired in real time with the rate of one frame per second. The system performance was evaluated initially via acquisition of two-dimensional optoacoustic images of small blood volumes in prostate tissue phantoms. Clinical ex-vivo studies of prostatectomy specimen were also performed and compared with transrectal ultrasound.

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Valeri G. Andreev, Anatoly E. Ponomarev, P. Mark Henrichs, Massoud Motamedi, Eduardo Orihuela M.D., Eduardo Eyzaguirre, and Alexander A. Oraevsky "Detection of prostate cancer with opto-acoustic tomography", Proc. SPIE 4960, Biomedical Optoacoustics IV, (1 July 2003); https://doi.org/10.1117/12.483489

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