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5 June 2003 Simulation of trabecular bone sample x-ray microradiography
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Osteoporosis is a disease characterized by a decrease of bone mineral density as well as by architecture modification leading to an increase of fracture risk. This paper is part of study investigating the possibility to extract some structural parameters quantifying trabecular bone architecture from radiographies realized in vivo. The first step of the study is the definition of optimum radiographic conditions (X-ray spectrum, detector) as well as the development of adapted image processing tools to extract relevant indexes characterizing architecture. Therefore a simulation process computing synthetic radiographies from trabecular bone samples has been developed. This process is done in three distinct steps: (1) Computation of a very high spatial resolution 3D μCT volume of a human trabecular bone sample from a series of acquisitions with a microtomography system using synchrotron radiation. (2) Transformation of the μCT volume in a materials voxel volume. (3) Simulation of the radiography projection by using the X-ray radiographic simulation software Sindbad. The simulation software provides a lot of parameters which can be easily modified (spectra, materials, geometry, detector...) so that its use for an optimisation purpose is very practical. Comparison of simulated and experimental radiographies performed under synchrotron radiation microtomography configuration validates the accuracy of our simulation process. Simulated radiographs under several clinical conditions are also presented.
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Joachim Tabary, Jean Marc Dinten, Regis Guillemaud, and Francoise Peyrin "Simulation of trabecular bone sample x-ray microradiography", Proc. SPIE 5030, Medical Imaging 2003: Physics of Medical Imaging, (5 June 2003);

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