Unilateral pleural effusion in an animal model: evaluation of lung function with EBCT

Wolfgang A. Recheis; Leo Pallwein; Peter Soegner; Ralph Faschingbauer; Georg Schmidbauer; Axel Kleinsasser; Alexander Loeckinger; Christoph Hoermann; Dieter zur Nedden

doi:10.1117/12.480319

2 May 2003 Unilateral pleural effusion in an animal model: evaluation of lung function with EBCT

Wolfgang A. Recheis, Leo Pallwein, Peter Soegner, Ralph Faschingbauer, Georg Schmidbauer, Axel Kleinsasser, Alexander Loeckinger, Christoph Hoermann, Dieter zur Nedden

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Proceedings Volume 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications; (2003) https://doi.org/10.1117/12.480319
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

The purpsoe was to evaluate the influence of a right-sided pleural effusion on the lung aeration dynamics in the respiratory cycle during pressure controlled ventilation. Pleural effusion was simulated by infusion of 3% gelatin into the pleural cavity in steps of 300ml totaling 1200ml in four anesthetized pigs. After each step, volume scans and respirator gated 50ms scans at a constant table position (carina niveau) were taken. The dynamic changes of the previously defined air-tissue ratios (in steps of 100HU) were evaluated in three separate regions of left and right lung: a ventral, an intermediate and a dorsal area. The affected side revealed dramatic alveolar collapse. There was a shift of the lung density to higher air-tissue ratios (+200HU) but showing the same air-tissue ratio dynamics. A slight lateral shift of 32mm (±14mm) the mediastinum was measured. The unaffected side showed no increase in the air-tissue ratios caused by hyperinflation but an increase of density due to mediastinal shift. Air-tissue ratio dynamics remained unchanged on the unaffected side compared to baseline measurements. We visualized the ventilation mismatch caused by pleural effusion. The contra-lateral lung is not affected by unilateral pleural effusion. Pressure controlled ventilation prevents hyper-inflation of non-dependent lung areas.

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Wolfgang A. Recheis, Leo Pallwein, Peter Soegner, Ralph Faschingbauer, Georg Schmidbauer, Axel Kleinsasser, Alexander Loeckinger, Christoph Hoermann, and Dieter zur Nedden "Unilateral pleural effusion in an animal model: evaluation of lung function with EBCT", Proc. SPIE 5031, Medical Imaging 2003: Physiology and Function: Methods, Systems, and Applications, (2 May 2003); https://doi.org/10.1117/12.480319

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KEYWORDS

Lung

Image segmentation

Animal model studies

Computed tomography

Image processing

Image analysis

Tissues

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