Hippocampal shape analysis: surface-based representation and classification

Li Shen; James Ford; Fillia Makedon; Andrew Saykin

doi:10.1117/12.480851

15 May 2003 Hippocampal shape analysis: surface-based representation and classification

Li Shen, James Ford, Fillia Makedon, Andrew Saykin

Proceedings Volume 5032, Medical Imaging 2003: Image Processing; (2003) https://doi.org/10.1117/12.480851
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

Surface-based representation and classification techniques are studied for hippocampal shape analysis. The goal is twofold: (1) develop a new framework of salient feature extraction and accurate classification for 3D shape data; (2) detect hippocampal abnormalities in schizophrenia using this technique. A fine-scale spherical harmonic expansion is employed to describe a closed 3D surface object. The expansion can then easily be transformed to extract only shape information (i.e., excluding translation, rotation, and scaling) and create a shape descriptor comparable across different individuals. This representation captures shape features and is flexible enough to do shape modeling, identify statistical group differences, and generate similar synthetic shapes. Principal component analysis is used to extract a small number of independent features from high dimensional shape descriptors, and Fisher's linear discriminant is applied for pattern classification. This framework is shown to be able to perform well in distinguishing clear group differences as well as small and noisy group differences using simulated shape data. In addition, the application of this technique to real data indicates that group shape differences exist in hippocampi between healthy controls and schizophrenic patients.

Citation Download Citation

Li Shen, James Ford, Fillia Makedon, and Andrew Saykin "Hippocampal shape analysis: surface-based representation and classification", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); https://doi.org/10.1117/12.480851

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