Overcoming activation-induced registration errors in fMRI

Jeffery J. Orchard; Chen Greif; Gene H. Golub; Bruce Bjornson; M. Stella Atkins

doi:10.1117/12.480849

15 May 2003 Overcoming activation-induced registration errors in fMRI

Jeffery J. Orchard, Chen Greif, Gene H. Golub, Bruce Bjornson, M. Stella Atkins

Author Affiliations +

Proceedings Volume 5032, Medical Imaging 2003: Image Processing; (2003) https://doi.org/10.1117/12.480849
Event: Medical Imaging 2003, 2003, San Diego, California, United States

Abstract

It has been shown that the presence of a blood oxygen level dependent (BOLD) signal in high-field (3T and higher) fMRI datasets can cause stimulus-correlated registration errors, especially when using a least-squares registration method. These errors can result in systematic inaccuracies in activation detection. The authors have recently proposed a new method to solve both the registration and activation detection least-squares problems simultaneously. This paper gives an outline of the new method, and demonstrates its robustness on simulated fMRI datasets containing various combinations of motion and activation. In addition to a discussion of the merits of the method and details on how it can be efficiently implemented, it is shown that, compared to the standard approach, the new method consistently reduces false-positive activations by two thirds and reduces false-negative activations by one third.

Citation Download Citation

Jeffery J. Orchard, Chen Greif, Gene H. Golub, Bruce Bjornson, and M. Stella Atkins "Overcoming activation-induced registration errors in fMRI", Proc. SPIE 5032, Medical Imaging 2003: Image Processing, (15 May 2003); https://doi.org/10.1117/12.480849

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