Comparative studies on cervical and colonic malignancies using FTIR microspectroscopy

Shaul Mordechai; Shlomo Mark; A. Podshyvalov; Keren Kantarovich; Y. Bernshtain; Ahmad Salman; Vitaly Erukhimovitch; Hugo Guterman; Jed Goldstein; Shmuel Argov; R. Jagannathan

doi:10.1117/12.484147

1 August 2003 Comparative studies on cervical and colonic malignancies using FTIR microspectroscopy

Shaul Mordechai, Shlomo Mark, A. Podshyvalov, Keren Kantarovich, Y. Bernshtain, Ahmad Salman, Vitaly Erukhimovitch, Hugo Guterman, Jed Goldstein, Shmuel Argov, R. Jagannathan

Author Affiliations +

Proceedings Volume 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II; (2003) https://doi.org/10.1117/12.484147
Event: NDE for Health Monitoring and Diagnostics, 2003, San Diego, California, United States

Abstract

IR spectroscopy provides a new diagnostic tool due to its sensitivity to molecular composition and structure in cells, which accompany transformation from healthy to diseased state. The IR spectrum of a sample is, therefore, a biochemical fingerprint. It has been found that the most significant changes occur in the mid-IR spectral range 3-25 mm. Encouraging results have been reported in the literature on various types of cancers, such as human breast, lung, colon, cervical, and leukemia using FT-IR microspectroscopy. Much progress has also been made by several groups on IR spectral maps and IR imaging with good agreement between the data and the histopathological information. In an attempt to characterize healthy and diseased tissues, infrared microspectroscopy of cervical and colon human tissues was studied using an infrared microscopy. The comparative qualitative and quantitative changes detected using FTIR microspectroscopy are discussed.

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Shaul Mordechai, Shlomo Mark, A. Podshyvalov, Keren Kantarovich, Y. Bernshtain, Ahmad Salman, Vitaly Erukhimovitch, Hugo Guterman, Jed Goldstein, Shmuel Argov, and R. Jagannathan "Comparative studies on cervical and colonic malignancies using FTIR microspectroscopy", Proc. SPIE 5047, Smart Nondestructive Evaluation and Health Monitoring of Structural and Biological Systems II, (1 August 2003); https://doi.org/10.1117/12.484147

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