Fluorescence diagnostics in oncological gynecology

Ludmila A. Belyaeva; Leila V. Adamyan; Vladimir P. Kozachenko; Alexander A. Stratonnikov; Eugene F. Stranadko; Victor B. Loschenov

doi:10.1117/12.518631

13 October 2003 Fluorescence diagnostics in oncological gynecology

Ludmila A. Belyaeva, Leila V. Adamyan, Vladimir P. Kozachenko, Alexander A. Stratonnikov, Eugene F. Stranadko, Victor B. Loschenov

Author Affiliations +

Proceedings Volume 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV; (2003) https://doi.org/10.1117/12.518631
Event: Saratov Fall Meeting 2002 Laser Physics and Photonics, Spectroscopy, and Molecular Modeling III; Coherent Optics of Ordered and Random Media III, 2002, Saratov, Russian Federation

Abstract

The method of fluorescent diagnostics (FD) of tumors is a promising tool that may allow to increase sensitivity of tumor detection especially at initial stages. One of the most promising photosensitizers today is 5-aminolevulinic acid (5-ALA) that, actually, is not photosensitizer itself but precursor of protoporphyrin IX (PpIX). This paper deals with cancer diagnostics in gynecology by means of ALA-induced Pp IX laser-fluorescence spectroscopy. The tissue fluorescence spectra in vivo were studied in patients with various pathologies of ovaries, uterine and vulva after 5-aminolevulinic acid administration. It was shown that different pathologies varies in accumulation of Pp IX. Coefficient of fluorescence k_f for normal tissue is not high, but exceptions are endometrium and mucous membrane of uterine tubes. Benign tumors of uterus and ovary have low values of k_f, but polyps of endometrium exhibit high k_f. Optical express-biopsy is important for diagnosis of ovarian cancer and micrometastatic spread. Coefficients of diagnostic contrast were determined for cancer of endometrium, cervical cancer, vulvar cancer.

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Ludmila A. Belyaeva, Leila V. Adamyan, Vladimir P. Kozachenko, Alexander A. Stratonnikov, Eugene F. Stranadko, and Victor B. Loschenov "Fluorescence diagnostics in oncological gynecology", Proc. SPIE 5068, Saratov Fall Meeting 2002: Optical Technologies in Biophysics and Medicine IV, (13 October 2003); https://doi.org/10.1117/12.518631

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