Bayesian estimation of optical properties of the human head via 3D structural MRI

Alexander H. Barnett; Joseph P. Culver; A. Gregory Sorensen M.D.; Anders M. Dale; David A. Boas

doi:10.1117/12.501184

15 October 2003 Bayesian estimation of optical properties of the human head via 3D structural MRI

Alexander H. Barnett, Joseph P. Culver, A. Gregory Sorensen M.D., Anders M. Dale, David A. Boas

Proceedings Volume 5138, Photon Migration and Diffuse-Light Imaging; (2003) https://doi.org/10.1117/12.501184
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Knowledge of the baseline optical properties of the tissues of the human head is essential for absolute cerebral oximetry, and for quantitative studies of brain activation. In this work we numerically model the utility of signals from a small 6-optode time-resolved diffuse optical tomographic apparatus for inferring baseline scattering and absorption coefficients of the scalp, skull and brain, when complete geometric information is available from magnetic resonance imaging (MRI). We use an optical model where MRI-segmented tissues are assumed homogeneous. We introduce a noise model capturing both photon shot noise and forward model numerical accuracy, and use Bayesian inference to predict errorbars and correlations on the measurments. We also sample from the full posterior distribution using Markov chain Monte Carlo. We conclude that ~ 10⁶ detected photons are sufficient to measure the brain’s scattering and absorption to a few percent. We present preliminary results using a fast multi-layer slab model, comparing the case when layer thicknesses are known versus unknown.

Citation Download Citation

Alexander H. Barnett, Joseph P. Culver, A. Gregory Sorensen M.D., Anders M. Dale, and David A. Boas "Bayesian estimation of optical properties of the human head via 3D structural MRI", Proc. SPIE 5138, Photon Migration and Diffuse-Light Imaging, (15 October 2003); https://doi.org/10.1117/12.501184

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KEYWORDS

Brain

Magnetic resonance imaging

Tissues

Head

Skull

Signal detection

Diffusion

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