Two-photon absorption induced drug delivery from polymeric intraocular lenses

Norbert A. Hampp; Hee-Cheol Kim; Stefan Kreiling; Lutz Hesse; Andreas Greiner

doi:10.1117/12.497976

16 October 2003 Two-photon absorption induced drug delivery from polymeric intraocular lenses

Norbert A. Hampp, Hee-Cheol Kim, Stefan Kreiling, Lutz Hesse, Andreas Greiner

Proceedings Volume 5142, Therapeutic Laser Applications and Laser-Tissue Interactions; (2003) https://doi.org/10.1117/12.497976
Event: European Conferences on Biomedical Optics 2003, 2003, Munich, Germany

Abstract

Secondary cataracts are quite often observed after implantation of polymeric intraocular lenses. The reason for this complication is that lens epithelial cells remain in the capsular bag when the natural lens is removed. They begin proliferation and cause secondary cataracts. It is not desireable to add cell toxic agents at the time of the implantation because wound healing is negatively affected. We have developed polymeric intraocular lenses which are equipped with a drug depot which may be released non-invasively through photochemical treatment. In the example presented the drug is 5-fluoruracil (5FU) which is covalently bound to the polymer. Deliberation of 5FU from the polymer is done photochemically. Since light is transmitted permanently through the artificial intraocular lens and wearing of special glasses by the patient should be omitted conventional photochemistry is not a suitable tool for the drug release. The polymer-5FU linkage is designed in a way that it has a high two-photon absorption cross-section. Two-photon absorption is used to selectively release 5FU from the lens. The one-photon reaction is blocked since the cornea does absorb UV light. The principle shown here is not limited to 5FU but may be applied to other drugs also.

Citation Download Citation

Norbert A. Hampp, Hee-Cheol Kim, Stefan Kreiling, Lutz Hesse, and Andreas Greiner "Two-photon absorption induced drug delivery from polymeric intraocular lenses", Proc. SPIE 5142, Therapeutic Laser Applications and Laser-Tissue Interactions, (16 October 2003); https://doi.org/10.1117/12.497976

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